AMBROXOL INHIBITS INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR PRODUCTION IN HUMAN MONONUCLEAR-CELLS

被引：33

作者：

BIANCHI, M ^{[1
]}

MANTOVANI, A ^{[1
]}

ERROI, A ^{[1
]}

DINARELLO, CA ^{[1
]}

GHEZZI, P ^{[1
]}

机构：

[1] TUFTS UNIV,NEW ENGLAND MED CTR,DIV GEOG MED & INFECT DIS,BOSTON,MA 02111

来源：

AGENTS AND ACTIONS | 1990年 / 31卷 / 3-4期

关键词：

D O I：

10.1007/BF01997619

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have studied the effect of Ambroxol on the production of Interleukin-1 (IL-1) and Tumor Necrosis Factor (TNF) in human mononuclear cells (MNC). For this purpose MNC were cultured for 24 h in the presence of endotoxin and different doses of Ambroxol. The results indicate that Ambroxol markedly inhibited IL-1 and TNF production at doses of 10-100 μg/ml, without any apparent toxicity. © 1990 Birkhäuser Verlag.

引用

页码：275 / 279

页数：5

共 17 条

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