A NEW POTENT INHIBITOR OF LIPID-PEROXIDATION INVITRO AND INVIVO, THE HEPATOPROTECTIVE DRUG ANISYLDITHIOLTHIONE

被引：76

作者：

MANSUY, D ^{[1
]}

SASSI, A ^{[1
]}

DANSETTE, PM ^{[1
]}

PLAT, M ^{[1
]}

机构：

[1] FAC PHARM CHATENAY MALABRY, CHIM THERAPEUT LAB, F-92290 CHATENAY MALABRY, FRANCE

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1986年 / 135卷 / 03期

关键词：

D O I：

10.1016/0006-291X(86)91029-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The drug anisyldithiolthione (ADT) acted as a good inhibitor of lipid peroxidation induced in rat liver microsomes either chemically by FeSO4 and reducing agents (cysteine or ascorbate) or enzymatically by NADPH and CCl4. ADT was found as potent as propylgallate with IC50 around 2 .mu.M and much more potent than vitamin E and levamisole. ADT was also found as a good inhibitor of ethane exhalation by rats treated by CCl4 (ID50 .apprx. 5 mg per kg) and by mice intoxicated by acetaminophen (ID50 .apprx. 0.7 mg per kg). At doses as low as 5 mg per kg it completely suppressed ethane exhalation by acetaminophen-intoxicated mice and also protected them very efficiently against mortality caused by acetaminophen overdose. The inhibitory effect of ADT toward lipid peroxidation seems to be linked to the presence of its dithiolthione function.

引用

页码：1015 / 1021

页数：7

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