ENHANCED RELEASE OF IMMUNOREACTIVE CGRP AND SUBSTANCE-P FROM SPINAL DORSAL HORN SLICES OCCURS DURING CARRAGEENAN INFLAMMATION

被引：119

作者：

GARRY, MG ^{[1
]}

HARGREAVES, KM ^{[1
]}

机构：

[1] UNIV MINNESOTA,SCH MED,DEPT PHARMACOL,MINNEAPOLIS,MN 55455

来源：

BRAIN RESEARCH | 1992年 / 582卷 / 01期

关键词：

CALCITONIN GENE-RELATED PEPTIDE; SUBSTANCE-P; INFLAMMATION; CARRAGEENAN; DORSAL HORN; SPINAL CORD; PAIN;

D O I：

10.1016/0006-8993(92)90328-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In vitro superfusion was used to examine the effect of inflammation on the release of immunoreactive calcitonin gene-related peptide (iCGRP) and substance P(iSP) from the dorsal horn of rats. Three hours after carrageenan, hindpaws exhibited hyperalgesia, edema, and hyperthermia. Spontaneous and capsaicin-evoked release of iCGRP and iSP were significantly increased following inflammation. The enhanced release of iCGRP and iSP in the dorsal horn may serve as a biochemical marker for the development of hyperalgesia.

引用

页码：139 / 142

页数：4

共 12 条

[1] THE EFFECTS OF DORSAL RHIZOTOMY AND SPINAL-CORD ISOLATION ON CALCITONIN GENE-RELATED PEPTIDE-LABELED TERMINALS IN THE RAT LUMBAR DORSAL HORN
CHUNG, K
LEE, WT
CARLTON, SM
[J]. NEUROSCIENCE LETTERS, 1988, 90 (1-2) : 27 - 32
[2] DRAISCI G, UNPUB CHANGES TACHYK
[3] FITZGERALD M, 1983, PAIN, V15, P145
[4] A NEW AND SENSITIVE METHOD FOR MEASURING THERMAL NOCICEPTION IN CUTANEOUS HYPERALGESIA
HARGREAVES, K
DUBNER, R
BROWN, F
FLORES, C
JORIS, J
[J]. PAIN, 1988, 32 (01) : 77 - 88
[5] DIFFERENTIAL RELEASE OF COEXISTING NEUROTRANSMITTERS - FREQUENCY-DEPENDENCE OF THE EFFLUX OF SUBSTANCE-P, THYROTROPIN RELEASING HORMONE AND [H-3] SEROTONIN FROM TISSUE-SLICES OF RAT VENTRAL SPINAL-CORD
IVERFELDT, K
SERFOZO, P
ARNESTO, LD
BARTFAI, T
[J]. ACTA PHYSIOLOGICA SCANDINAVICA, 1989, 137 (01): : 63 - 71
[6] CALCITONIN GENE-RELATED PEPTIDE IS A POTENT INHIBITOR OF SUBSTANCE-P DEGRADATION
LEGREVES, P
NYBERG, F
TERENIUS, L
HOKFELT, T
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1985, 115 (2-3) : 309 - 311
[7] LUNDBERG JM, 1987, NEUROSCIENCE, V23, P693
[8] CAPSAICIN-INDUCED RELEASE OF CALCITONIN GENE-RELATED PEPTIDE FROM DORSAL HORN SLICES IS ENHANCED IN ADJUVANT ARTHRITIC RATS
NANAYAMA, T
KURAISHI, Y
OHNO, H
SATOH, M
[J]. NEUROSCIENCE RESEARCH, 1989, 6 (06) : 569 - 572
[9] RELEASE OF SUBSTANCE-P FROM THE SPINAL DORSAL HORN IS ENHANCED IN POLYARTHRITIC RATS
OKU, R
SATOH, M
TAKAGI, H
[J]. NEUROSCIENCE LETTERS, 1987, 74 (03) : 315 - 319
[10] PEPTIDE COEXISTENCE IN AXON TERMINALS WITHIN THE SUPERFICIAL DORSAL HORN OF THE RAT SPINAL-CORD
PLENDERLEITH, MB
HALLER, CJ
SNOW, PJ
[J]. SYNAPSE, 1990, 6 (04) : 344 - 350

← 1 2 →