EASY DIRECT STEREOSELECTIVE AND REGIOSELECTIVE FORMATION OF BETA-HYDROXY NITRILES BY REACTION OF 1,2-EPOXIDES WITH POTASSIUM CYANIDE IN THE PRESENCE OF METAL-SALTS

被引:75
作者
CHINI, M [1 ]
CROTTI, P [1 ]
FAVERO, L [1 ]
MACCHIA, F [1 ]
机构
[1] UNIV PISA,DIPARTIMENTO CHIM BIOORGAN,VIA BONANNO 33,I-56126 PISA,ITALY
关键词
BETA-HYDROXY NITRILES; EPOXIDES OPENING REACTIONS; REGIOSELECTIVITY; CATALYSTS;
D O I
10.1016/S0040-4039(00)92305-0
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A simple efficient, anti stereoselective, and highly regioselective method for the synthesis of beta-hydroxy nitriles by the direct opening of 1,2-epoxides with KCN in acetonitrile, in the presence of metal salts, is described. This new method appears to be competitive with the other methods previously reported.
引用
收藏
页码:4775 / 4778
页数:4
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