IMPORTANCE OF ENZYME AND SOLVENT PHYSICAL-PROPERTIES FOR THE BIOCOMPATIBILITY RELATIONSHIP OF ALPHA-AMINO-ACID ESTER HYDROLASE

被引:17
作者
MACNAUGHTAN, MD
DAUGULIS, AJ
机构
[1] Department of Chemical Engineering, Queen's University, Kingston
关键词
BIOCOMPATIBILITY; SOLVENT SELECTION; EXTRACTIVE BIOCATALYSIS; LOG-P;
D O I
10.1016/0141-0229(93)90034-Y
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The enzyme alpha-amino acid ester hydrolase was used with a variety of organic solvents to further explore the relationships between biocompatibility and solvent physical properties. Biocompatibility was shown to be system-specific; that is, the inflection point of the characteristic log P trend (approximately 1.5) was specific to the enzyme employed, while the biocompatibility of solvents that were exceptions to the trend was dependent on the extent of agitation. In addition, phase toxic solvents all possessed a high interfacial tension with water. Finally, while the source of the enzyme may be significant, the extent of purification does not appear to be a factor in biocompatibility.
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页码:114 / 119
页数:6
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