HUMAN HLA CLASS I-RESTRICTED AND HLA CLASS II-RESTRICTED CLONED CYTOTOXIC T-LYMPHOCYTES IDENTIFY A CLUSTER OF EPITOPES ON THE MEASLES-VIRUS FUSION PROTEIN

被引:44
作者
VANBINNENDIJK, RS [1 ]
VERSTEEGVANOOSTEN, JPM [1 ]
POELEN, MCM [1 ]
BRUGGHE, HF [1 ]
HOOGERHOUT, P [1 ]
OSTERHAUS, ADME [1 ]
UYTDEHAAG, FGCM [1 ]
机构
[1] NATL INST PUBL HLTH & ENVIRONM PROTECT,DEPT BACTERIAL VACCINE DEV,3720 BA BILTHOVEN,NETHERLANDS
关键词
D O I
10.1128/JVI.67.4.2276-2284.1993
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The transmembrane fusion (F) glycoprotein of measles virus is an important target antigen of human HLA class I- and class II-restricted cytotoxic T lymphocytes (CTL). Genetically engineered F proteins and nested sets of synthetic peptides spanning the F protein were used to determine sequences of F recognized by a number of F-specific CTL clones. Combined N- and C-terminal deletions of the respective peptides revealed that human HLA class I and HLA class II-restricted CTL efficiently recognize nonapeptides or decapeptides representing epitopes of F. Three distinct sequences recognized by three different HLA class II (DQw1, DR2, and DR4/w53)-restricted CTL clones appear to cluster between amino acids 379 and 466 of F, thus defining an important T-cell epitope area of F. Within this same region, a nonamer peptide of F was found to be recognized by an HLA-B27-restricted CTL clone, as expected on the basis of the structural homology between this peptide and other known HLA-B27 binding peptides.
引用
收藏
页码:2276 / 2284
页数:9
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