NEUROCHEMICAL PROFILES IN CEREBROSPINAL-FLUID OF STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS

被引：67

作者：

TOGASHI, H ^{[1
]}

MATSUMOTO, M ^{[1
]}

YOSHIOKA, M ^{[1
]}

HIROKAMI, M ^{[1
]}

MINAMI, M ^{[1
]}

SAITO, H ^{[1
]}

机构：

[1] HIGASHI NIPPON GAKUEN UNIV, FAC PHARMACOL SCI, DEPT PHARMACOL, ISHIKARI, HOKKAIDO 06102, JAPAN

来源：

NEUROSCIENCE LETTERS | 1994年 / 166卷 / 01期

关键词：

STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RAT; ACETYLCHOLINE; NOREPINEPHRINE; SEROTONIN; CEREBROSPINAL FLUID; VASCULAR DEMENTIA;

D O I：

10.1016/0304-3940(94)90854-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The purpose of the present study was to evaluate stroke-prone spontaneously hypertensive rats (SHRSP) neurochemically by determining the cerebrospinal fluid (CSF) levels of acetylcholine (ACh), norepinephrine (NE) and serotonin (5-HT) as an index of central neuronal activity. The CSF ACh levels of 15- to 20-week-old SHRSP were significantly lower than those of age-matched Wistar Kyoto rats (WKY) both under the urethane/alpha-chloralose anesthesia and in freely moving conditions. The difference in the CSF ACh levers between SHRSP and WKY was more marked at 30-40 weeks. Sustained changes were not observed in the CSF NE and 5-HT levels. Thus, the progressive dysfunction in the central cholinergic system may characterize the pathophysiological state of this animal moder with cerebral lesions caused by continuous high blood pressure.

引用

页码：117 / 120

页数：4

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