MDR1 (MULTIDRUG-RESISTANCE) GENE-EXPRESSION IN HUMAN PRIMARY LIVER-CANCER AND CIRRHOSIS

被引：58

作者：

CHENIVESSE, X

FRANCO, D

BRECHOT, C

机构：

[1] HOP ANTOINE BECLERE,SERV CHIRURG,F-92141 CLAMART,FRANCE

[2] HOP LAENNEC,UNITE HEPATOL,F-75340 PARIS 07,FRANCE

来源：

JOURNAL OF HEPATOLOGY | 1993年 / 18卷 / 02期

关键词：

MDR1; LIVER CANCER; CIRRHOSIS;

D O I：

10.1016/S0168-8278(05)80243-0

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

MDR1 RNA levels were analysed in patients with hepatocellular carcinoma (HCC), benign liver tumors or cirrhosis. None of the patients with HCC had received chemotherapy. MDR1 RNA levels were increased relative to a normal liver specimen in 15/26 liver cancers, 2/6 benign liver tumors and 0/8 tumor-free cirrhotic livers. MDR1 was also overexpressed in cirrhotic non-tumorous liver tissues of some patients with HCC. The results indicate that the MDR1 gene is overexpressed in liver tumors and some preneoplastic lesions and that might account for the very poor response of primary liver cancers to chemotherapy.

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收藏

页码：168 / 172

页数：5

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