THROUGH-SPACE AMIDE ACTIVATION OF C-H BONDS IN TRIANGULANES

被引：35

作者：

EATON, PE

LUKIN, KA

机构：

[1] Department of Chemistry, The University of Chicago, Chicago, Illinois 60637

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1993年 / 115卷 / 24期

关键词：

D O I：

10.1021/ja00077a041

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Amide activation for anion formation from properly located CH groups in triangulanes is shown to provide for stereospecific functionalization. Thus, treatment of exo amide 20a with (TMP)2Mg followed by CO2 carboxylation leads to syn substitution in the adjacent ring (21). The same treatment of endo amide 20b gives endo (syn) substitution in the remote ring (22).

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页码：11370 / 11375

页数：6

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