LYMPHOMA WITH RECURRENT CYCLES OF SPONTANEOUS REMISSION AND RELAPSE - POSSIBLE ROLE OF APOPTOSIS

被引：35

作者：

KAUFMANN, Y ^{[1
]}

MANY, A ^{[1
]}

RECHAVI, G ^{[1
]}

MOR, O ^{[1
]}

BINIAMINOV, M ^{[1
]}

ROSENTHAL, E ^{[1
]}

LEVANON, M ^{[1
]}

DAVIDSOHN, J ^{[1
]}

AIZMAN, I ^{[1
]}

MARK, Z ^{[1
]}

BROKSIMONI, F ^{[1
]}

RAMOT, B ^{[1
]}

机构：

[1] TEL AVIV UNIV,SACKLER SCH MED,IL-69978 TEL AVIV,ISRAEL

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 1995年 / 332卷 / 08期

关键词：

D O I：

10.1056/NEJM199502233320805

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We describe a patient with a unique mantle-cell lymphoma, with cycles of acute illness alternating with spontaneous remissions. During the acute phase the patient had fever, generalized lymphadenopathy, hepatosplenomegaly, increased liver-enzyme concentrations, leukocytosis, and thrombocytopenia. These bouts remitted after two to three weeks without treatment. Fifteen such cycles were documented over a period of 50 months. During the acute phase blast-like B lymphocytes in the blood expressed surface IgM, IgD, and CD5, whereas during clinical remission a small population of IgM and CD5+ lymphocytes persisted. Two B-cell clones with differently rearranged heavy-chain genes consistently appeared in the blood during the… © 1995, Massachusetts Medical Society. All rights reserved.

引用

页码：507 / 510

页数：4

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