MARKERS OF CARTILAGE MATRIX METABOLISM IN HUMAN JOINT FLUID AND SERUM - THE EFFECT OF EXERCISE

被引：79

作者：

ROOS, H

DAHLBERG, L

HOERRNER, LA

LARK, MW

THONAR, EJMA

SHINMEI, M

LINDQVIST, U

LOHMANDER, LS

机构：

[1] Department of Orthopaedics, University Hospital

[2] Department of Biochemical and Molecular Pathology, Merck Research Laboratories, Rahway

[3] Departments of Biochemistry and Internal Medicine, Rush Medical College, Chicago

[4] Department of Orthopedic Surgery, National Defense Medical College 3-2 Namiki, Tokorozawa, Saitama

[5] Department of Clinical Chemistry, Academic Hospital

来源：

OSTEOARTHRITIS AND CARTILAGE | 1995年 / 3卷 / 01期

关键词：

KNEE JOINT; CARTILAGE; JOINT FLUID; SERUM; MARKERS; EXERCISE;

D O I：

10.1016/S1063-4584(05)80033-0

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

The concentrations of cartilage proteoglycan (aggrecan), stromelysin-1, tissue inhibitor of metalloproteinases-1 (TIMP-1) and procollagen II C-propeptide in knee joint fluid and the levels of aggrecan, hyaluronan and keratan sulfate in serum were measured before and after exercise in 33 healthy athletes. The samples before exercise were obtained after 24 h rest from running or soccer and the samples after exercise were obtained 30-60 min after the exercise. Nine athletes ran on a treadmill for 60 min, 16 ran on road for 80 min and 8 played one soccer game (90 min). A reference group of 28 patients with knee pain but not evidence of joint pathology or injury was used for comparison. In joint fluid no single marker from the degradative processes in cartilage matrix changed significantly with exercise but all showed a rising trend. All markers except stromelysin showed lower concentrations in athletes at rest compared to the reference group. In serum from runners before exercise the concentration of keratan sulfate was significantly higher than in both the soccer and reference groups and further increased after exercise. The increase in markers after exercise may reflect an effect of mechanical loading in combination with a possible high turnover rate of body cartilage matrix in these individuals.

引用

页码：7 / 14

页数：8

共 48 条

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