NADPH-FORMING DEHYDROGENASES IN ADIPOSE-TISSUE OF OBESE AND NONOBESE DIABETICS

被引：4

作者：

BELFIORE, F ^{[1
]}

LOVECCHIO, L ^{[1
]}

BORZI, V ^{[1
]}

IANNELLO, S ^{[1
]}

机构：

[1] UNIV CATANIA, OSPED GARIBALDI, SCH MED, CLIN MED 1, I-95123 CATANIA, ITALY

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 1976年 / 25卷 / 07期

关键词：

D O I：

10.1016/0026-0495(76)90143-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The activity of glucose-6-phosphate dehydrogenase (EC 1.1.1.49) of adipose tissue was markedly decreased, both on a protein and on a fat cell number basis, in nonobese diabetics compared to control subjects, but was unchanged in obese diabetics. Average value in the obese diabetics was about 4-fold higher than in nonobese diabetics. On the other hand, the activity of malate dehydrogenase (decarboxylating) (NADP) (EC 1.1.1.40) was reduced by about 50% in both groups of diabetics. In obese diabetics NADPH-generation in the adipose tissue, necessary for several biosynthetic processes, might be less severely depressed than in lean diabetics.

引用

页码：723 / 725

页数：3

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