BENZODIAZEPINES IMPAIR A BEHAVIORAL-EFFECT INDUCED BY STIMULATION OF 5-HT1B RECEPTORS

被引:9
作者
FRANCES, H
KHIDICHIAN, F
MONIER, C
机构
[1] Inserm U-302, Département de Pharmacologie, Faculté de Médecine Pitié-Salpêtrière, 75634 Paris Cedex 13
关键词
5-HT1B stimulation; Benzodiazepines; Isolated mice; Nonbenzodiazepine tranquillizing drugs;
D O I
10.1016/0091-3057(90)90368-R
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Seven days of isolation induce in mice a social behavioral deficit (decrease in escape attempts) reversed by TFMPP acting through activation of HT1B receptors. The present experiments were performed to investigate the interaction between tranquillizing drugs and one aspect of the serotonergic functioning through the TFMPP-induced increase in escape attempts. The benzodiazepines diazepam, alprazolam, triazolam and chlordiazepoxide impaired significantly TFMPP-induced increase in escape attempts at behaviorally inactive doses. Buspirone opposed TFMPP effect, but the active doses 4 and 16 mg/kg alone decreased the number of escape attempts. ICS 205-930 in a large dose range (0.001-1 mg/kg) modified neither the number of escape attempts nor the increase induced by TFMPP. Chronic (11 days) treatment with buspirone (16 mg/kg) or ICS 205-930 (1 mg/kg) modified neither the number of escape attempts of isolated mice nor the increase induced by TFMPP. These results suggest that tranquillizing drugs of the benzodiazepines group, but not of other groups, interact with the 5-HT1B receptors; they add to knowledge of relations between benzodiazepines and serotonin by specifying the involvement of 5-HT1B receptors. © 1990.
引用
收藏
页码:841 / 845
页数:5
相关论文
共 40 条
[1]  
BARRETT JE, 1986, J PHARMACOL EXP THER, V238, P1009
[2]   ENHANCING GABAERGIC TRANSMISSION REVERSES THE AVERSIVE STATE IN RATS INDUCED BY ELECTRICAL-STIMULATION OF THE PERIAQUEDUCTAL GREY REGION [J].
BOVIER, P ;
BROEKKAMP, CLE ;
LLOYD, KG .
BRAIN RESEARCH, 1982, 248 (02) :313-320
[3]   ANIMAL-MODELS FOR ANXIETY AND RESPONSE TO SEROTONERGIC DRUGS [J].
BROEKKAMP, CLE ;
BERENDSEN, HHG ;
JENCK, F ;
VANDELFT, AML .
PSYCHOPATHOLOGY, 1989, 22 :2-12
[4]  
CARLI M, 1988, PSYCHOPHARMACOLOGY, V94, P359
[5]   SEROTONIN FUNCTION IN ANXIETY .2. EFFECTS OF THE SEROTONIN AGONIST MCPP IN PANIC DISORDER PATIENTS AND HEALTHY-SUBJECTS [J].
CHARNEY, DS ;
WOODS, SW ;
GOODMAN, WK ;
HENINGER, GR .
PSYCHOPHARMACOLOGY, 1987, 92 (01) :14-24
[6]   EFFECT OF DIAZEPAM ON FATE OF INTRACISTERNALLY INJECTED SEROTONIN-C-14 [J].
CHASE, TN ;
KATZ, RI ;
KOPIN, IJ .
NEUROPHARMACOLOGY, 1970, 9 (02) :103-&
[7]  
COSTALL B, 1988, BRIT J PHARMACOL, V93, pP195
[8]  
DAVIS M, 1986, PSYCHOPHARMACOL BULL, V22, P837
[9]   SEROTONERGIC MECHANISMS IN THE BEHAVIORAL-EFFECTS OF BUSPIRONE AND GEPIRONE [J].
EISON, AS ;
EISON, MS ;
STANLEY, M ;
RIBLET, LA .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1986, 24 (03) :701-707
[10]   ISOLATION-INDUCED SOCIAL BEHAVIORAL DEFICIT - A PROPOSED MODEL OF HYPERREACTIVITY WITH A BEHAVIORAL-INHIBITION [J].
FRANCES, H ;
LIENARD, C ;
FERMANIAN, J ;
LECRUBIER, Y .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1989, 32 (03) :637-642