DIETARY CALCIUM BLOCKS LITHIUM TOXICITY IN HAMSTERS WITHOUT AFFECTING CIRCADIAN-RHYTHMS

被引:15
作者
KLEMFUSS, H
BAUER, TT
GREENE, KE
KRIPKE, DF
机构
[1] UNIV CALIF SAN DIEGO, DEPT NEUROSCI, LA JOLLA, CA 92093 USA
[2] UNIV BONN, W-5300 BONN, GERMANY
[3] UNIV CALIF SAN DIEGO, DEPT PSYCHIAT, LA JOLLA, CA 92093 USA
关键词
D O I
10.1016/0006-3223(92)90055-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Lithium can be toxic to rodents at plasma concentrations (0.6-1.2 mmol/L) that also phase delay circadian rhythms. In hamsters, raising the concentration of calcium in the diet from 0.1%-3% reduced weight loss and polydipsia caused by 0.4% lithium carbonate. Calcium ingestion did not affect plasma lithium concentration or the phase of the circadian wheel-running rhythm in lithium-treated animals. Calcium ingestion did not alter weight gain, salt or water intake, or circadian rhythms in hamsters not receiving lithium. Dietary calcium supplementation may prevent some toxic effects of lithium without interfering with other central nervous system actions.
引用
收藏
页码:315 / 321
页数:7
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