RESOLUTION OF CHLORPROMAZINE-INDUCED CUTANEOUS PIGMENTATION FOLLOWING SUBSTITUTION WITH LEVOMEPROMAZINE OR OTHER NEUROLEPTICS

被引:9
作者
BLOOM, D
KRISHNAN, B
THAVUNDAYIL, JX
LAL, S
机构
[1] DOUGLAS HOSP,RES CTR,6875 LASALLE BLVD,VERDUN H4H 1R3,PQ,CANADA
[2] MONTREAL GEN HOSP,DEPT PSYCHIAT,MONTREAL H3G 1A4,QUEBEC,CANADA
[3] MCGILL UNIV,DEPT PSYCHIAT,MONTREAL H3A 2T5,QUEBEC,CANADA
关键词
CHLORPROMAZINE; PIGMENTATION; LEVOMEPROMAZINE; NEUROLEPTIC; DRUG;
D O I
10.1111/j.1600-0447.1993.tb03360.x
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Eleven chronic schizophrenic patients with abnormal skin pigmentation associated with neuroleptic treatment were withdrawn from chlorpromazine (CPZ), which was replaced by levomepromazine (n = 4), trifluoperazine (n = 1) or thioproperazine (n = 1) as the sole neuroleptic, by a combination of these phenothiazines (n = 4) or with haloperidol plus pipotiazine (n = 1). Seven patients showed complete resolution of abnormal skin pigmentation over a period of 1-5 years and 4 markedly improved over 2.0-2.6 years of follow-up. Our observations suggest that neuroleptic-induced abnormal skin pigmentation is (i) predominantly, if not exclusively, a side effect of CPZ and (ii) reversible, providing that CPZ is withdrawn and sufficient time is allowed to elapse.
引用
收藏
页码:223 / 224
页数:2
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