CONVENIENT GENERATION OF 1-PROPYNYLLITHIUM - ONE-POT SYNTHESIS OF ACETYLENIC CARBINOLS FROM 1,2-DIBROMOPROPANE AND ALDEHYDES AND KETONES

被引：12

作者：

GRIBBLE, GW

JOYNER, HH

SWITZER, FL

机构：

[1] Department of Chemistry, Dartmouth College, Hanover

来源：

SYNTHETIC COMMUNICATIONS | 1992年 / 22卷 / 20期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1080/00397919208021126

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of 1,2-dibromopropane (1) with 3 equiv of lithium diisopropylamide (-60-degrees to 0-degrees-C, THF) generates 1-propynyllithium (2), which with aldehydes or ketones affords acetylenic carbinols 3 in 82-96% yields.

引用

页码：2997 / 3002

页数：6

共 13 条

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