TOTAL ASYMMETRIC SYNTHESES OF (+)-BLASTMYCINONE AND RELATED GAMMA-LACTONES

被引：50

作者：

NISHIDE, K ^{[1
]}

ARAMATA, A ^{[1
]}

KAMANAKA, T ^{[1
]}

INOUE, T ^{[1
]}

NODE, M ^{[1
]}

机构：

[1] KYOTO PHARMACEUT UNIV,KYOTO 607,JAPAN

来源：

TETRAHEDRON | 1994年 / 50卷 / 28期

关键词：

D O I：

10.1016/S0040-4020(01)85556-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The freeze of the conformer was realized by the introduction of an alkyl substituent at alpha-position of tetronic acid using a readily available none C-2 chiral auxiliary (SMP or RMP), and conducted the desired asymmetric gamma-methylation. Its application to expeditious total syntheses of (+)-blastmycinone (I) and (-)-3-epi-blastmycinone (2), and to the first total synthesis of (+)-(3R,4R,5R)-4-acetoxy-5-methyl-3-tetradecyltetrahydro-2(5H)-furanone (3) was described.

引用

页码：8337 / 8346

页数：10

共 33 条

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