EXPRESSION AND REGULATION OF STEROID 5-ALPHA-REDUCTASE 2 IN PROSTATE DISEASE

被引：83

作者：

SILVER, RI ^{[1
]}

WILEY, EL ^{[1
]}

DAVIS, DL ^{[1
]}

THIGPEN, AE ^{[1
]}

RUSSELL, DW ^{[1
]}

MCCONNELL, JD ^{[1
]}

机构：

[1] UNIV TEXAS,SW MED CTR,DEPT PATHOL & MOLEC GENET,DALLAS,TX 75230

来源：

JOURNAL OF UROLOGY | 1994年 / 152卷 / 02期

关键词：

PROSTATIC HYPERTROPHY; PROSTATIC NEOPLASMS; ANDROGENS; ANTIANDROGENS; DIHYDROTESTOSTERONE;

D O I：

10.1016/S0022-5347(17)32757-X

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The androgen dihydrotestosterone is synthesized by the enzyme steroid 5 alpha-reductase, and it is required for growth and development of the prostate. We used immunohistochemistry to examine the expression of the type 2 isozyme of 5 alpha-reductase in benign prostatic hyperplasia and prostate cancer. The type 2 isozyme is highly expressed within stromal cells in both disease states. No type 2 isozyme is detectable in a lymph node metastasis. Immunoblotting studies show that androgen ablation therapies substantially decrease isozyme expression in the epididymis but have a lesser effect on expression in the prostate. Finasteride therapy (2 weeks to 3 years) did not abolish expression of the prostatic type 2 isozyme nor did this drug treatment induce expression of the type 1 isozyme.

引用

页码：433 / 437

页数：5

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