THERAPEUTIC TRIAL OF MILACEMIDE IN PATIENTS WITH MYOCLONUS AND OTHER INTRACTABLE MOVEMENT-DISORDERS

被引：5

作者：

GORDON, MF ^{[1
]}

DIAZOLIVO, R ^{[1
]}

HUNT, AL ^{[1
]}

FAHN, S ^{[1
]}

机构：

[1] COLUMBIA PRESBYTERIAN MED CTR,INST NEUROL,DEPT NEUROL,710 W 168TH ST,NEW YORK,NY 10032

来源：

MOVEMENT DISORDERS | 1993年 / 8卷 / 04期

关键词：

MILACEMIDE; GLYCINE; MYOCLONUS; STIFF-PERSON SYNDROME; X-LINKED DYSTONIA; PROGRESSIVE SUPRANUCLEAR PALSY; CORTICAL-BASAL GANGLIONIC DEGENERATION; STRIATONIGRAL DEGENERATION;

D O I：

10.1002/mds.870080412

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We performed a therapeutic trial with the glycine precursor, milacemide, on 10 patients with intractable movement disorders. Six had myoclonus of various etiologies and one each had progressive supranuclear palsy, Filipino X-linked dystonia with parkinsonism, painful legs and moving toes, and stiff-person syndrome. Milacemide was initiated at a dose of 2,400 mg/day, orally, and increased gradually to a maximum of 4,800 mg/day. No clear-cut observable improvement occurred. There were no serious adverse effects.

引用

页码：484 / 488

页数：5

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