MITSUNOBU ACYLATION OF STERICALLY CONGESTED SECONDARY ALCOHOLS BY N,N,N',N'-TETRAMETHYLAZODICARBOXAMIDE-TRIBUTYLPHOSPHINE REAGENTS

被引：85

作者：

TSUNODA, T

YAMAMIYA, Y

KAWAMURA, Y

ITO, S

机构：

[1] Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 14期

关键词：

D O I：

10.1016/0040-4039(95)00299-R

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four secondary alcohols of different steric environment reacted with five carboxylic acids of different acidity in the presence of N,N,N',N'-tetramethylazodicarboxamide and tributylphosphine to give the corresponding epi-esters in better yield than with diethyl azodicarboxylate-triphenylphosphine in most cases. Of special merit is the combination of the new reagent system with p-methoxybenzoic acid to achieve complete inversion of sterically congested secondary alcohols.

引用

页码：2529 / 2530

页数：2

共 9 条

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