A COMPARATIVE-STUDY ON THE IMMUNE-RESPONSE OF SHEEP TO FOOT-AND-MOUTH-DISEASE VIRUS-VACCINE TYPE ASIA-1 PREPARED WITH DIFFERENT INACTIVANTS AND ADJUVANTS

被引：8

作者：

NAIR, SP

SEN, AK

机构：

来源：

COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES | 1992年 / 15卷 / 02期

关键词：

FOOT AND MOUTH DISEASE VIRUS; INACTIVATION; VACCINE; ADJUVANT; ANTIBODY; SHEEP;

D O I：

10.1016/0147-9571(92)90110-D

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Foot and mouth disease virus type Asia-1 was inactivated either with formaldehyde or binaryethylenimine (BEI). Inactivated vaccines were prepared incorporating aluminium hydroxide gel or mineral oil as an adjuvant. The antibody response to the adult sheep was studied by ELISA and SN test for a period of 6 months. There was no difference in the antibody response between vaccines inactivated with formaldehyde or BEI. Whereas significant difference in the antibody response was observed between gel and oil vaccines. The high titres of antibody stimulated by oil vaccines persisted longer than those of gel vaccines within the period of study.

引用

页码：117 / 124

页数：8

共 16 条

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