DEVELOPMENTAL SEGREGATION IN THE AFFERENT-PROJECTIONS TO MAMMALIAN AUDITORY HAIR-CELLS

被引:107
作者
ECHTELER, SM
机构
[1] Auditory Physiology Laboratory, Dept. of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208
关键词
COCHLEA; NEURONAL DEVELOPMENT; AUDITORY SYSTEM;
D O I
10.1073/pnas.89.14.6324
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The mammalian ear contains two types of auditory receptors, inner and outer hair cells, that lie in close proximity to each other within the sensory epithelium of the cochlea. In adult mammals, these two classes of auditory hair cells are innervated by separate populations of afferent neurons that differ strikingly in their cellular morphology and their pattern of arborization within the cochlea. At present, it is unclear when or how these distinctive patterns of cochlear innervation emerge and become segregated during development. In the present study, an in vitro horseradish peroxidase labeling method was used to examine the formation of individual auditory neuron arbors at the same location within the apex of the developing gerbil cochlea. At birth, most cochlear neurons displayed peripheral arbors that embraced both inner and outer hair cell receptors. During the next 6 days, however, the arbors of individual cochlear afferents become confined to either the inner or outer hair cell zone, and thus there is a complete segregation of afferent innervation. This neural segregation occurs principally through the withdrawal of inappropriate connections to the outer hair cell system and is completed well before hearing commences.
引用
收藏
页码:6324 / 6327
页数:4
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