SUBSTITUTED 1-[(BENZOFURAN-2-YL)-PHENYLMETHYL]-IMIDAZOLES AS POTENT INHIBITORS OF AROMATASE INVITRO AND IN FEMALE RATS INVIVO

被引：45

作者：

WHOMSLEY, R

FERNANDEZ, E

NICHOLLS, PJ

SMITH, HJ

LOMBARDI, P

PESTELLINI, V

机构：

[1] UWCC,WELSH SCH PHARM,CARDIFF,WALES

[2] MENARINI SUD,I-0040 POMEZIA,ITALY

[3] A MENARINI IND FARMACEUT RIUNITE,I-50131 FLORENCE,ITALY

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1993年 / 44卷 / 4-6期

关键词：

D O I：

10.1016/0960-0760(93)90279-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Substituted 1-[(benzofuran-2-yl)-phenylmethyl]-imidazoles are a new class of potent aromatase inhibitor with in vitro IC50 values < 10 nM for certain members using human placental enzyme. At a dose of 2mg/kg in PMSG-stimulated rats, selected compounds effectively reduce the oestradiol levels by 82-98%.

引用

页码：675 / 676

页数：2

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