PERCUTANEOUS CT LYMPHOGRAPHY WITH PERFLUBRON - IMAGING EFFICACY IN RABBITS AND MONKEYS

被引：29

作者：

WOLF, GL

ROGOWSKA, J

HANNA, GK

HALPERN, EF

机构：

[1] Ctr. Imaging and Pharmaceutical Res., Massachusetts General Hospital, Charleston, MA 02129

来源：

RADIOLOGY | 1994年 / 191卷 / 02期

关键词：

BROMINE; LYMPHATIC SYSTEM; CT; LYMPHOGRAPHY;

D O I：

10.1148/radiology.191.2.8153329

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

PURPOSE: To evaluate the imaging efficacy of percutaneous lymphography performed with injection of perflubron emulsions and computed tomography (CT). MATERIALS AND METHODS: Thin-section CT was used to image lymph nodes in 116 rabbits and six monkeys. Quantitative measures of regional lymph node enhancement were obtained 4 hours to 21 days after subcutaneous injection of perflubron (0.1-0.5 mt per injection site). Lymph node enhancement was calculated in Hounsfield units and converted to bromine concentration with standards that were imaged at the same time. RESULTS: Excellent enhancement of regional lymph nodes in both groups of animals was obtained. Nodal enhancement was linearly related to dose and was sustained for 20 days; maximum enhancement was seen 2 days after injection. Massage of the injection site increased delivery of the perflubron emulsion to regional lymph nodes. CONCLUSION: In rabbits and monkeys, percutaneous CT lymphography effectively depicts the intranodal distribution of macrophages in normal lymph nodes.

引用

页码：501 / 505

页数：5

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