EFFECTS OF ANTIARRHYTHMIC AGENTS CLASSIFIED AS CLASS-III GROUP ON ISCHEMIA-INDUCED MYOCARDIAL DAMAGE IN CANINE HEARTS

被引：15

作者：

SANO, T

SUGIYAMA, S

TAKI, K

HANAKI, Y

SHIMADA, Y

OZAWA, T

机构：

[1] NAGOYA UNIV,FAC MED,DEPT BIOMED CHEM,SHOWA KU,NAGOYA,AICHI 466,JAPAN

[2] NAGOYA UNIV,FAC MED,DEPT ANESTHESIOL,NAGOYA,AICHI 466,JAPAN

[3] NAGOYA UNIV,FAC MED,DEPT INTERNAL MED,NAGOYA,AICHI 466,JAPAN

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1990年 / 99卷 / 03期

关键词：

D O I：

10.1111/j.1476-5381.1990.tb12971.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The cardioprotective effects of antiarrhythmic agents classified as class III, amiodarone, sotalol and E-4031, were investigated in anaesthetized dogs. The left anterior descending coronary artery was occluded for 2 h. Heart mitochondria were prepared from both the ischaemic and non-ischaemic areas, and their function was estimated polarographically. Activities of the lysosomal enzymes, N-acetyl-β-glucosaminidase and β-glucuronidase, were measured in each fraction. Two hour occlusion induced ventricular arrhythmias, and amiodarone, sotalol and E-4031 greatly suppressed the development of arrhythmias. Amiodarone, sotalol and E-4031 significantly protected mitochondria against ischaemia, and prevented ischaemia-induced leakage of lysosomal enzymes. Antiarrhythmic agents classified as class III show cardioprotective effects, which might participate in their antiarrhythmic effect.

引用

页码：577 / 581

页数：5

共 36 条

[1] CLASS-III DRUGS - AMIODARONE [J].