ASSIGNMENT OF THE ABSOLUTE-CONFIGURATION TO WINTERSTEIN ACID, R-3-DIMETHYLAMINO-3-PHENYL PROPIONIC-ACID, BY THE ASYMMETRIC-SYNTHESIS OF HOMOCHIRAL (S)-(+)-ETHYL 3-DIMETHYLAMINO-3-PHENYL PROPIONATE

被引:20
作者
DAVIES, SG
DUPONT, J
EASTON, RJC
机构
[1] The Dyson Perrins Laboratory, Oxford, OX1 3QY, South Park Road
关键词
D O I
10.1016/S0957-4166(00)86312-0
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
The asymmetric synthesis of homochiral (S)-(+)-ethyl 3-dimethylamino-3-phenyl propionate, via stereoselective Michael addition of lithium dimethylamide to (S)-Z-[(η5-C5H5)-Fe(CO)(PPh3)COCHCHPh] and oxidative decomplexation, establishes the absolute configuration of Winterstein's acid, 3-dimethylamino-3-phenyl propionic acid, derived from Taxine B, as R. © 1990.
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页码:279 / 280
页数:2
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