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STRIKING HOMOLOGY OF THE VARIABLE N-TERMINAL AS WELL AS THE CONSERVED CORE DOMAINS OF THE MOUSE AND HUMAN TATA-FACTORS (TFIID)

被引：82
作者：
TAMURA, T
SUMITA, K
FUJINO, I
AOYAMA, A
HORIKOSHI, M
HOFFMANN, A
ROEDER, RG
MURAMATSU, M
MIKOSHIBA, K
机构：
[1] NATL INST BASIC BIOL,DIV BEHAV & NEUROBIOL,OKAZAKI,AICHI 444,JAPAN
[2] OSAKA UNIV,INST PROT RES,DIV MACROMOLEC FUNCT,SUITA,OSAKA 565,JAPAN
[3] ROCKEFELLER UNIV,BIOCHEM & MOLEC BIOL LAB,NEW YORK,NY 10021
[4] UNIV TOKYO,FAC MED,DEPT BIOCHEM,BUNKYO KU,TOKYO 113,JAPAN
来源：
NUCLEIC ACIDS RESEARCH | 1991年 / 19卷 / 14期
基金：
美国国家卫生研究院;
关键词：
RNA POLYMERASE-II; GENERAL TRANSCRIPTION FACTOR; IMMEDIATE EARLY PROTEIN; MYELIN BASIC-PROTEIN; BOX-BINDING-PROTEIN; PROMOTER INTERACTIONS; SCHIZOSACCHAROMYCES-POMBE; SACCHAROMYCES-CEREVISIAE; PREINITIATION COMPLEX; FUNCTIONAL DOMAINS;
D O I：
10.1093/nar/19.14.3861
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A complementary DNA (cDNA) encoding a mouse TFIID (mIID) was isolated from mouse brain cDNA libraries. The 316 amino acid sequence deduced from cDNA sequences revealed the presence of an amino-terminal region enriched in serine, threonine, and proline (STP-cluster), an uninterrupted stretch of 13 glutamine residues (Q-run), a second STP-cluster, and a conserved carboxy-terminal region. Amino acid sequences of the first STP-cluster and the conserved carboxy-terminal region were identical to those of the human TFIID (hIID). However, the Q-run was considerably shorter than that in hIID and sequences in the second STP-cluster diverged from those of the hIID. The murine TFIID transcript is expressed as a 2 kilobase poly(A)+ RNA in the mouse brain. Southern blot analysis identified a single gene copy per haploid mouse genome.
引用
收藏
页码：3861 / 3865
页数：5
相关论文
共 35 条
[1]   THE PSEUDORABIES IMMEDIATE EARLY PROTEIN STIMULATES INVITRO TRANSCRIPTION BY FACILITATING TFIID - PROMOTER INTERACTIONS [J].
ABMAYR, SM ;
WORKMAN, JL ;
ROEDER, RG .
GENES & DEVELOPMENT, 1988, 2 (05) :542-553
[2]   FUNCTION OF A YEAST TATA ELEMENT-BINDING PROTEIN IN A MAMMALIAN TRANSCRIPTION SYSTEM [J].
BURATOWSKI, S ;
HAHN, S ;
SHARP, PA ;
GUARENTE, L .
NATURE, 1988, 334 (6177) :37-42
[3]   5 INTERMEDIATE COMPLEXES IN TRANSCRIPTION INITIATION BY RNA POLYMERASE-II [J].
BURATOWSKI, S ;
HAHN, S ;
GUARENTE, L ;
SHARP, PA .
CELL, 1989, 56 (04) :549-561
[4]   CLONING OF THE GENE ENCODING THE YEAST PROTEIN BTF1Y, WHICH CAN SUBSTITUTE FOR THE HUMAN TATA BOX-BINDING FACTOR [J].
CAVALLINI, B ;
FAUS, I ;
MATTHES, H ;
CHIPOULET, JM ;
WINSOR, B ;
EGLY, JM ;
CHAMBON, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (24) :9803-9807
[5]   A YEAST ACTIVITY CAN SUBSTITUTE FOR THE HELA-CELL TATA BOX FACTOR [J].
CAVALLINI, B ;
HUET, J ;
PLASSAT, JL ;
SENTENAC, A ;
EGLY, JM ;
CHAMBON, P .
NATURE, 1988, 334 (6177) :77-80
[6]   SPT15, THE GENE ENCODING THE YEAST TATA BINDING-FACTOR TFIID, IS REQUIRED FOR NORMAL TRANSCRIPTION INITIATION INVIVO [J].
EISENMANN, DM ;
DOLLARD, C ;
WINSTON, F .
CELL, 1989, 58 (06) :1183-1191
[7]   STRIKING CONSERVATION OF TFIID IN SCHIZOSACCHAROMYCES-POMBE AND SACCHAROMYCES-CEREVISIAE [J].
FIKES, JD ;
BECKER, DM ;
WINSTON, F ;
GUARENTE, L .
NATURE, 1990, 346 (6281) :291-294
[8]   PRIMARY STRUCTURE AND FUNCTIONAL EXPRESSION OF THE INOSITOL 1,4,5-TRISPHOSPHATE-BINDING PROTEIN-P400 [J].
FURUICHI, T ;
YOSHIKAWA, S ;
MIYAWAKI, A ;
WADA, K ;
MAEDA, N ;
MIKOSHIBA, K .
NATURE, 1989, 342 (6245) :32-38
[9]   ARABIDOPSIS-THALIANA CONTAINS 2 GENES FOR TFIID [J].
GASCH, A ;
HOFFMANN, A ;
HORIKOSHI, M ;
ROEDER, RG ;
CHUA, NH .
NATURE, 1990, 346 (6282) :390-394
[10]   ISOLATION OF THE GENE ENCODING THE YEAST TATA BINDING-PROTEIN TFIID - A GENE IDENTICAL TO THE SPT15 SUPPRESSOR OF TY ELEMENT INSERTIONS [J].
HAHN, S ;
BURATOWSKI, S ;
SHARP, PA ;
GUARENTE, L .
CELL, 1989, 58 (06) :1173-1181
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