STUDIES ON RAS ONCOGENE ACTIVATION IN ENDOMETRIAL CARCINOMA

被引:53
作者
FUJIMOTO, I [1 ]
SHIMIZU, Y [1 ]
HIRAI, Y [1 ]
CHEN, JT [1 ]
TESHIMA, H [1 ]
HASUMI, K [1 ]
MASUBUCHI, K [1 ]
TAKAHASHI, M [1 ]
机构
[1] SRL INC,CYTOPATHOL & GENET LABS,TOKYO,JAPAN
关键词
D O I
10.1006/gyno.1993.1033
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The frequency of K-ras point mutation(PM) at codon 12 was studied in 45 patients with endometrial carcinoma. In vitro amplification of target sequences of DNA extracted from endometrial cancer tissues by polymerase chain reaction and dot blotting with oligonucleotide hybridization were performed. Ten of 45 endometrial carcinomas disclosed K-ras PM at codon 12 (22.2%). Transition from GGT to GAT was most frequent in PM(41.7%). Simultaneously, double PM (GAT/GCT) were also detected in 2 cases. No relationship appeared to be present between PM and clinical prognosis such as clinical stage, histological type, histological grade of differentiation, depth of myometrial invasion, and ascitic cytology. The positive rates of lymph node metastasis tended to be higher in the group with positive PM than in the group without PM. K-ras and C-myc gene amplifications were found in 2 (5.1%) and 3 (7.7%) of 39 cases, respectively. No PM of H-ras at codons 12 and 61 was detected. Our results showed that the PM of K-ras gene at codon 12 was a fairly common event in genetic abnormality and suggested it would have some role in the progression of carcinogenesis in endometrial carcinoma. © 1993 Academic Press, Inc.
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页码:196 / 202
页数:7
相关论文
共 29 条
[1]   MOST HUMAN CARCINOMAS OF THE EXOCRINE PANCREAS CONTAIN MUTANT C-K-RAS GENES [J].
ALMOGUERA, C ;
SHIBATA, D ;
FORRESTER, K ;
MARTIN, J ;
ARNHEIM, N ;
PERUCHO, M .
CELL, 1988, 53 (04) :549-554
[2]   HIGHER FREQUENCY OF POINT MUTATIONS IN THE C-K-RAS 2 GENE IN HUMAN COLORECTAL ADENOMAS WITH SEVERE ATYPIA THAN IN CARCINOMAS [J].
ANDO, M ;
MARUYAMA, M ;
OTO, M ;
TAKEMURA, K ;
ENDO, M ;
YUASA, Y .
JAPANESE JOURNAL OF CANCER RESEARCH, 1991, 82 (03) :245-249
[3]  
BARBACID M, 1987, ANNU REV BIOCHEM, V56, P776
[4]   PREVALENCE OF RAS GENE-MUTATIONS IN HUMAN COLORECTAL CANCERS [J].
BOS, JL ;
FEARON, ER ;
HAMILTON, SR ;
VERLAANDEVRIES, M ;
VANBOOM, JH ;
VANDEREB, AJ ;
VOGELSTEIN, B .
NATURE, 1987, 327 (6120) :293-297
[5]   GENETIC MECHANISMS IN TUMOR INITIATION AND PROGRESSION .10. THE RAS GENE FAMILY AND HUMAN CARCINOGENESIS [J].
BOS, JL .
MUTATION RESEARCH, 1988, 195 (03) :255-271
[6]  
BOS JL, 1989, CANCER RES, V49, P4682
[7]   ANALYSIS OF ONCOGENE ALTERATIONS IN HUMAN ENDOMETRIAL CARCINOMA - PREVALENCE OF RAS MUTATIONS [J].
BOYD, J ;
RISINGER, JI .
MOLECULAR CARCINOGENESIS, 1991, 4 (03) :189-195
[8]  
ENOMOTO T, 1990, CANCER RES, V50, P6139
[9]  
ENOMOTO T, 1991, CANCER RES, V51, P5308
[10]   ANALYSIS OF RAS GENE-MUTATIONS IN ACUTE MYELOID-LEUKEMIA BY POLYMERASE CHAIN-REACTION AND OLIGONUCLEOTIDE PROBES [J].
FARR, CJ ;
SAIKI, RK ;
ERLICH, HA ;
MCCORMICK, F ;
MARSHALL, CJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (05) :1629-1633