NANCE-HORAN SYNDROME - LINKAGE ANALYSIS IN A FAMILY FROM THE NETHERLANDS

被引：12

作者：

BERGEN, AAB

TENBRINK, J

SCHUURMAN, EJM

BLEEKERWAGEMAKERS, EM

机构：

[1] Netherlands Ophthalmic Research Institute, 1100 AC Amsterdarn

来源：

GENOMICS | 1994年 / 21卷 / 01期

关键词：

D O I：

10.1006/geno.1994.1248

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Linkage analysis was carried out in a Dutch family with Nance-Horan (NH) syndrome. Close linkage without recombination between NH and the Xp loci DXS207, DXS43, and DXS365 (z(max) = 3.23) was observed. Multipoint linkage analysis and the analysis of recombinations in multiple informative meioses suggest the genetic order Xcen-DMD (exon 49)-DXS451-(NH, DXS207, DXS365, DXS43)-(STS, DXF30)-Xpter. These data refine the localization of the NH locus on the distal Xp. (C) 1994 Academic Press, Inc.

引用

页码：238 / 240

页数：3

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