INTERACTIONS OF THE HAV-VP3 (61-78) PEPTIDE WITH MONOLAYERS AND BILAYERS

被引：10

作者：

BOGDAM, K

ALSINA, MA

HARO, I

MARTIN, I

REIG, F

机构：

[1] CSIC,CID,DEPT PEPTIDE,E-08034 BARCELONA,SPAIN

[2] ELTE,INST ORGAN CHEM,BUDAPEST,HUNGARY

[3] UNIV BARCELONA,FAC PHARM,PHYSICOCHEM UNIT,E-08028 BARCELONA,SPAIN

来源：

LANGMUIR | 1994年 / 10卷 / 12期

关键词：

D O I：

10.1021/la00024a038

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis, on a solid support, of a Hepatitis A viral protein peptide, HAV-VP3 (61-78), is described. The interaction of the peptide with, dipalmitoylphosphatidylcholine (DPPC), dipalmitoylphosphatidylglycerol (DPPG), dioleoylphosphatidylcholine (DOPC), and distearoylphosphatidylcholine (DSPC) has been studied, using Liposomes and monomolecular layers as biomembrane models. Changes in fluidity of the bilayers induced by this peptide were determined by means of polarizable probes such as 8-anilino-1-naphthalenesulfonic acid (ANS) and 1,6-diphenyl-1,3,5-hexatriene (DPH). In this way liposomes can be used as carriers for small immunogenic peptides.

引用

页码：4618 / 4623

页数：6

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