INFLUENCE OF ROUTE OF ADMINISTRATION ON PROGESTERONE METABOLISM

被引：64

作者：

DELIGNIERES, B

DENNERSTEIN, L

BACKSTROM, T

机构：

[1] UNIV MELBOURNE, DEPT COMMUNITY MED, CARLTON, VIC 3053, AUSTRALIA

[2] UNIV UPPSALA, DEPT OBSTET & GYNAECOL, S-75185 UPPSALA, SWEDEN

来源：

MATURITAS | 1995年 / 21卷 / 03期

关键词：

VAGINAL ADMINISTRATION; ORAL ADMINISTRATION; PROGESTONES; 5-ALPHA-PREGNANOLONE; 5-BETA-PREGNANOLONE;

D O I：

10.1016/0378-5122(94)00882-8

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

While inducing similar progesterone levels, the ratio of 5 alpha- and 5 beta-pregnanolone/progesterone plasma concentrations has been dramatically increased after oral as opposed to vaginal administration, in a cross-over study. The known psychotropic effects of 5 alpha- and 5 beta-pregnanolone lead to different indications and precautions for oral and vaginal administration of progesterone.

引用

收藏

页码：251 / 257

页数：7

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