Toxicity of iron and hydrogen peroxide: The Fenton reaction

被引：1060

作者：

Winterbourn, CC

机构：

[1] Department of Pathology, Christchurch School of Medicine, Christchurch

来源：

TOXICOLOGY LETTERS | 1995年 / 82-3卷

关键词：

iron mediated injury; Fenton reaction; hydroxyl radical toxicity;

D O I：

10.1016/0378-4274(95)03532-X

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Iron and hydrogen peroxide are capable of oxidizing a wide range of substrates and causing biological damage. The reaction, referred to as the Fenton reaction, is complex and capable of generating both hydroxyl radicals and higher oxidation states of the iron. The mechanism and how it is affected by different chelators, and the interpretation of results obtained in biological systems, are discussed.

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页码：969 / 974

页数：6

相关论文

共 25 条

[1]

[Anonymous], 2015, FREE RADICAL BIO MED

[2] THE IRON-BINDING AND HYDROXYL RADICAL SCAVENGING ACTION OF ANTI-INFLAMMATORY DRUGS [J].

ARUOMA, OI ;

HALLIWELL, B .

XENOBIOTICA, 1988, 18 (04) :459-470

[3] APPARENT HYDROXYL RADICAL PRODUCTION BY PEROXYNITRITE - IMPLICATIONS FOR ENDOTHELIAL INJURY FROM NITRIC-OXIDE AND SUPEROXIDE [J].

BECKMAN, JS ;

BECKMAN, TW ;

CHEN, J ;

MARSHALL, PA ;

FREEMAN, BA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (04) :1620-1624

[4] ESR SPIN-TRAPPING STUDIES INTO THE NATURE OF THE OXIDIZING SPECIES FORMED IN THE FENTON REACTION - PITFALLS ASSOCIATED WITH THE USE OF 5,5-DIMETHYL-1-PYRROLINE-N-OXIDE IN THE DETECTION OF THE HYDROXYL RADICAL [J].

BURKITT, MJ .

FREE RADICAL RESEARCH COMMUNICATIONS, 1993, 18 (01) :43-57

[5] A SITE-SPECIFIC MECHANISM FOR FREE-RADICAL INDUCED BIOLOGICAL DAMAGE - THE ESSENTIAL ROLE OF REDOX-ACTIVE TRANSITION-METALS [J].

CHEVION, M .

FREE RADICAL BIOLOGY AND MEDICINE, 1988, 5 (01) :27-37

[6] DESFERRIOXAMINE (DESFERAL) AND SUPEROXIDE FREE-RADICALS - FORMATION OF AN ENZYME-DAMAGING NITROXIDE [J].

DAVIES, MJ ;

DONKOR, R ;

DUNSTER, CA ;

GEE, CA ;

JONAS, S ;

WILLSON, RL .

BIOCHEMICAL JOURNAL, 1987, 246 (03) :725-729

[7] DESFERRIOXAMINE INHIBITION OF THE HYDROXYL RADICAL-LIKE REACTIVITY OF PEROXYNITRITE - ROLE OF THE HYDROXAMIC GROUPS [J].

DENICOLA, A ;

SOUZA, JM ;

GATTI, RM ;

AUGUSTO, O ;

RADI, R .

FREE RADICAL BIOLOGY AND MEDICINE, 1995, 19 (01) :11-19

[8]

GARDNER PR, 1991, J BIOL CHEM, V266, P19328

[9] THE FENTON REAGENTS [J].

GOLDSTEIN, S ;

MEYERSTEIN, D ;

CZAPSKI, G .

FREE RADICAL BIOLOGY AND MEDICINE, 1993, 15 (04) :435-445

[10] CELLULAR-REGULATION OF THE IRON-RESPONSIVE ELEMENT BINDING-PROTEIN - DISASSEMBLY OF THE CUBANE IRON-SULFUR CLUSTER RESULTS IN HIGH-AFFINITY RNA-BINDING [J].

HAILE, DJ ;

ROUAULT, TA ;

HARFORD, JB ;

KENNEDY, MC ;

BLONDIN, GA ;

BEINERT, H ;

KLAUSNER, RD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (24) :11735-11739