IBOTENIC ACID LESIONS OF THE MEDIAL PREFRONTAL CORTEX POTENTIATE FG-7142-INDUCED ATTENUATION OF EXPLORATORY ACTIVITY IN THE RAT

被引：37

作者：

JASKIW, GE ^{[1
]}

WEINBERGER, DR ^{[1
]}

机构：

[1] NIMH,NEUROSCI CTR ST ELIZABETH,INTRAMURAL RES PROGRAM,WASHINGTON,DC 20032

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1990年 / 36卷 / 03期

关键词：

Exploration; FG-7142; Ibotenic acid; Locomotion; Prefrontal cortex; Stress;

D O I：

10.1016/0091-3057(90)90276-N

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Six weeks after induction of bilateral sham or ibotenic acid lesions of the medial prefrontal cortex (MPFC), groups of rats were injected with the anxiogenic β-carboline FG-7142 (15 mg/kg IP) or vehicle (VEH) before exposure to a novel open field. The attenuation of exploratory activity by FG-7142 was markedly enchanced in the MPFC-lesioned rats. The results suggest that the behavioral effects of MPFC lesions may be amplified under stressful conditions. Secondly, the inhibition of exploratory activity by FG-7142 does not depend on its action within the MPFC. © 1990.

引用

页码：695 / 697

页数：3

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