CHEMICAL AND MICROBIOLOGICAL INVESTIGATIONS OF METAL-ION INTERACTION WITH NORFLOXACIN

被引：36

作者：

ALKAYSI, HN

ABDELHAY, MH

SALEM, MS

GHARAIBEH, AM

NAWAS, TE

机构：

[1] JORDAN UNIV SCI & TECHNOL,FAC MED,IRBID,JORDAN

[2] UNIV ALEXANDRIA,FAC PHARM,ALEXANDRIA,EGYPT

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1992年 / 87卷 / 1-3期

关键词：

NORFLOXACIN; NORFLOXACIN-METAL ION INTERACTION; ANTIMICROBIAL ACTIVITY; SPECTROPHOTOMETRY;

D O I：

10.1016/0378-5173(92)90229-U

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This report describes a spectrophotometric study on the interaction between norfloxacin (NFX) and metal ions (Al3+, Mg2+ and Ca2+). Two buffeTS of pH 3.6 and 8.8 were used. A shift in absorption maximum was observed and the stoichiometry of the complex was determined using the Job and molar ratio methods. The ratios were NFX: Al3+, 2:1 and 3:1 for the NFX: Mg2+ complex. The formation of a complex with Al3+ enhanced the water solubility of the drug. Microbiological studies indicated decreased activity of norfloxacin in the presence of metal ions.

引用

页码：73 / 77

页数：5

共 11 条

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