CD14 RECEPTOR-MEDIATED UPTAKE OF NONOPSONIZED MYCOBACTERIUM-TUBERCULOSIS BY HUMAN MICROGLIA

被引：145

作者：

PETERSON, PK

GEKKER, G

HU, SX

SHENG, WS

ANDERSON, WR

ULEVITCH, RJ

TOBIAS, PS

GUSTAFSON, KV

MOLITOR, TW

CHAO, CC

机构：

[1] HENNEPIN CTY MED CTR, DEPT PATHOL, MINNEAPOLIS, MN 55415 USA

[2] UNIV MINNESOTA, SCH MED, MINNEAPOLIS, MN 55455 USA

[3] Scripps Res Inst, RES INST, DEPT IMMUNOL, LA JOLLA, CA 92037 USA

[4] UNIV MINNESOTA, COLL VET MED, ST PAUL, MN 55108 USA

来源：

INFECTION AND IMMUNITY | 1995年 / 63卷 / 04期

关键词：

D O I：

10.1128/IAI.63.4.1598-1602.1995

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This study was carried out to determine the role of CD14 receptors in the uptake of nonopsonized Mycobacterium tuberculosis by human microglia. Treatment of microglial cell cultures with antibodies to CD14 or with soluble CD14 significantly blocked infection by M. tuberculosis H37Rv, suggesting that CD14 receptors could facilitate entry of nonopsonized tubercle bacilli into macrophages within the brain.

引用

页码：1598 / 1602

页数：5

共 25 条

[1]

AISEN PS, 1994, AM J PSYCHIAT, V151, P1105

[2] BRAIN MICROGLIA CONSTITUTIVELY EXPRESS BETA-2 INTEGRINS [J].