MODIFICATION OF RADIATION-INDUCED CHROMOSOME-DAMAGE AND MICRONUCLEUS INDUCTION IN MOUSE BONE-MARROW BY MISONIDAZOLE AND HYPERTHERMIA

被引:8
作者
BISHT, KS [1 ]
DEVI, PU [1 ]
机构
[1] KASTURBA MED COLL & HOSP,DEPT RADIOBIOL,MANIPAL 576119,KARNATAKA,INDIA
关键词
D O I
10.3109/02841869509127204
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The effect of misonidazole (MISO), local hyperthermia (HT) and their combination on radiation-induced chromosome damage and:micronucleus (MN) induction was studied in mouse bone marrow cells, It was found that MISO treatment did not enhance the clastogenic effect of radiation, which indicates a lack of radiosensitization of bone marrow chromosomes, But post-irradiation HT increased the frequency of aberrant cells and MN, A combination of MISO and HT produced a significant increase in the frequency of radiation-induced aberrant cells and MN at all the radiation doses as compared to radiation alone, The percentage of aberrant cells as well as the percentage of MN showed a linear quadratic increase with radiation dose in all the treatment groups, At higher radiation doses, cells with >1 MN increased quadratically with a pronounced increase in cells bearing >2 MN and severely damaged cells (SDCs) at radiation doses above 3.0 Gy in the HT and MISO + HT traeated groups, Our results indicate that though MISO itself may not have a radiosensitizing effect on mouse chromosomes, a combination of MISO with HT can enhance the radiation damage in normal bone marrow.
引用
收藏
页码:913 / 918
页数:6
相关论文
共 26 条
[1]  
ARCANGELI G, 1980, CANCER, V45, P2707, DOI 10.1002/1097-0142(19800601)45:11<2707::AID-CNCR2820451102>3.0.CO
[2]  
2-6
[3]   DOSE-DEPENDENT INCREASE IN THE FREQUENCY OF MICRONUCLEI AND CHROMOSOMAL-ABERRATIONS BY MISONIDAZOLE IN MOUSE BONE-MARROW [J].
BISHT, KS ;
DEVI, PU .
MUTATION RESEARCH LETTERS, 1994, 325 (2-3) :57-63
[4]   HYPOXIC CELL RADIOSENSITIZERS - COMPARATIVE TESTS OF SOME ELECTRON AFFINIC COMPOUNDS USING EPIDERMAL-CELL SURVIVAL INVIVO [J].
DENEKAMP, J ;
MICHAEL, BD ;
HARRIS, SR .
RADIATION RESEARCH, 1974, 60 (01) :119-132
[5]  
Devi P. Uma, 1993, Strahlentherapie und Onkologie, V169, P196
[6]   MOUSE BONE-MARROW RESPONSE TO LOW-DOSES OF WHOLE-BODY GAMMA-IRRADIATION - INDUCTION OF MICRONUCLEI [J].
DEVI, PU ;
SHARMA, ASKVS .
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1990, 57 (01) :97-101
[7]  
DEVI PU, 1992, CURR SCI INDIA, V62, P691
[8]  
DEVI PU, 1993, STRAHLENTHER ONKOL, V10, P601
[9]  
DEWEY WC, 1989, HYPERTHERMIC ONCOLOG, V1, P75
[10]   COMBINED EFFECTS OF X-RAYS, RO-03-8799, AND HYPERTHERMIA ON GROWTH, NECROSIS, AND CELL-PROLIFERATION IN A MOUSE-TUMOR [J].
GEORGE, KC ;
STREFFER, C ;
PELZER, T .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1989, 16 (04) :1119-1122