ORAL TRIIODOTHYRONINE ADMINISTRATION LOWERS PLASMA FIBRONECTIN LEVELS IN HUMANS

被引:6
作者
ALEXANDER, CM [1 ]
LUM, SMC [1 ]
BOARMAN, C [1 ]
NICOLOFF, JT [1 ]
KUMAR, D [1 ]
机构
[1] UNIV SO CALIF, SCH MED, DEPT MED, LOS ANGELES, CA 90033 USA
来源
METABOLISM-CLINICAL AND EXPERIMENTAL | 1984年 / 33卷 / 07期
关键词
D O I
10.1016/0026-0495(84)90057-X
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Both serum triiodothyronine (T3) and plasma fibronectin values declined with fasting and increased with treatment of diabetic ketoacidosis in parallel manner. To evaluate the mechanism responsible for these changes, the effects of both oral T3 administration and fasting were examined in 6 healty, adult subjects. Initial plasma fibronectin values were normal in both groups. Despite a substantial rise in serum T3 values with oral T3 administration, plasma fibronectin fell in group 1 subjects. Fasting caused a significant decline in serum T3 levels, but only a small further decline of plasma fibronectin concentrations. Serum T3 levels rose after 1 wk of refeeding, whereas plasma fibronectin levels in group 1 did not return toward normal. Plasma fibronectin values did not change in group 2 subjects with oral T3, fasting, or refeeding. There is not simple cause-and-effect relationship between previously observed changes in plasma fibronectin and serum T3 concentrations. High doses of oral T3 will lower plasma fibronectin levels in subjects with initially normal plasma fibronectin values and a normal caloric intake.
引用
收藏
页码:608 / 611
页数:4
相关论文
共 19 条
  • [1] ALEXANDER CM, 1983, J CLIN ENDOCR METAB, V56, P279
  • [2] BRAY GA, 1973, AM J CLIN NUTR, V26, P715
  • [3] SEMIAUTOMATED RADIOIMMUNOASSAYS FOR TOTAL SERUM THYROXINE AND TRIIODOTHYRONINE
    CHALLAND, GS
    RATCLIFFE, WA
    RATCLIFFE, JG
    [J]. CLINICA CHIMICA ACTA, 1975, 60 (01) : 25 - 32
  • [4] DENO DC, 1982, FED PROC, V41, P706
  • [5] QUANTITATIVE AND QUALITATIVE EFFECTS OF L-TRIIODOTHYRONINE IN MASSIVE OBESITY
    HOLLINGSWORTH, DR
    AMATRUDA, TT
    SCHEIG, R
    [J]. METABOLISM, 1970, 19 (11): : 934 - +
  • [6] STARVATION-INDUCED ALTERATIONS OF CIRCULATING THYROID-HORMONE CONCENTRATIONS IN MAN
    MERIMEE, TJ
    FINEBERG, ES
    [J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 1976, 25 (01): : 79 - 83
  • [7] Mosher D F, 1980, Prog Hemost Thromb, V5, P111
  • [8] PEARLSTEIN E, 1980, MOL CELL BIOCHEM, V29, P103
  • [9] ENZYME-LINKED IMMUNOASSAY (ELISA) FOR CONNECTIVE-TISSUE COMPONENTS
    RENNARD, SI
    BERG, R
    MARTIN, GR
    FOIDART, JM
    ROBEY, PG
    [J]. ANALYTICAL BIOCHEMISTRY, 1980, 104 (01) : 205 - 214
  • [10] RICHARDS WO, 1983, SURGERY, V94, P210