CLINICAL AND BIOCHEMICAL ASPECTS OF DEPRESSIVE-DISORDERS .1. INTRODUCTION, CLASSIFICATION, AND RESEARCH TECHNIQUES

被引：21

作者：

CALDECOTTHAZARD, S

GUZE, BH

KLING, MA

KLING, A

BAXTER, LR

机构：

[1] UNIV CALIF LOS ANGELES, BIOMED & ENVIRONM SCI LAB, LOS ANGELES, CA 90024 USA

[2] UNIV CALIF LOS ANGELES, DEPT PSYCHIAT, LOS ANGELES, CA 90024 USA

[3] VET ADM MED CTR, DEPT PSYCHIAT, SEPULVEDA, CA 91343 USA

[4] NIMH, DIV INTRAMURAL RES PROGRAMS, CLIN NEUROENDOCRINOL BRANCH, BETHESDA, MD 20892 USA

来源：

SYNAPSE | 1991年 / 8卷 / 03期

关键词：

DEPRESSIVE DISORDERS; HUMANS; ANIMAL MODELS;

D O I：

10.1002/syn.890080306

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present review focuses on recent data from clinical and animal research concerning the biochemical bases of depressive disorders, diagnosis, and treatment. In addition to integrating these data, problems and future directions in this research are discussed. The review is presented in three parts. This study, Part I, describes diagnostic classification schemes for depressive disorders, some epidemiological and biological correlates of the classifications, and research techniques for investigating depressive disorders. Research techniques include animal models, human biochemical techniques, and Positron Emission Tomography. In a future issue, Part II will discuss various transmitter/receptor theories of depressive disorders, e.g., noradrenergic, serotonergic, cholinergic, and dopaminergic, GABAergic, and peptidergic theories. Also in a future issue, Part III will discuss treatments for depression and some of the controversies in the field.

引用

页码：185 / 211

页数：27

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