CONVENIENT PROCEDURE FOR THE REDUCTION OF BETA-ENAMINO KETONES - SYNTHESIS OF GAMMA-AMINO ALCOHOLS AND TETRAHYDRO-1,3-OXAZINES

被引：56

作者：

BARTOLI, G ^{[1
]}

CIMARELLI, C ^{[1
]}

PALMIERI, G ^{[1
]}

机构：

[1] UNIV CAMERINO,DIPARTIMENTO SCI CHIM,I-62032 CAMERINO,ITALY

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1994年 / 05期

关键词：

D O I：

10.1039/p19940000537

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

gamma-Amino alcohols 3 can be easily synthesized in very good yields by reduction of enaminones 1 with Na in (PrOH)-O-i-tetrahydrofuran. The reaction is fast, easy to perform, inexpensive and the easily accessible starting materials provide a convenient entry to gamma-amino alcohols. The relative configuration assignment of the diastereoisomeric gamma-amino alcohols obtained has been established by H-1 and C-13 NMR studies and unequivocally assigned by their cyclic tetrahydro-1,3-oxazine derivatives 4.

引用

页码：537 / 543

页数：7

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