BIPHASIC STRIATAL ACETYLCHOLINE-RELEASE DURING AND AFTER TRANSIENT CEREBRAL-ISCHEMIA IN GERBILS

被引:16
作者
BERTRAND, N
ISHII, H
BELEY, A
SPATZ, M
机构
[1] NINCDS,STROKE BRANCH,BDG 36,RM 4B12,BETHESDA,MD 20892
[2] FAC PHARM DIJON,PHARMACODYNAM & PHYSIOL PHARMACEUT LAB,DIJON,FRANCE
关键词
ACETYLCHOLINE; CEREBRAL ISCHEMIA; CHOLINE; MICRODIALYSIS; STRIATUM;
D O I
10.1038/jcbfm.1993.100
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Acetylcholine (ACh) release into the extracellular space was measured by HPLC with electrochemical detection after in vivo intracerebral microdialysis in the striatum of gerbils subjected to 15 min of bilateral carotid artery occlusion followed by 5 h of recirculation. Tissue ACh and choline (Ch) contents were also determined during ischemia and after 5, 30, 60, and 120 min of reflow. Fifteen minutes of ischemia led to a significant transient increase in extracellular ACh concentration (threefold after 7.5 min of ischemia) concomitant with a reduced endogenous ACh level (- 62%) and increased tissue Ch content (ninefold). Recirculation significantly reduced the ACh release during the early period of reflow (- 50% vs. basal level), followed by a significant increase in ACh release between 1 and 3 h of reflow (45-55% vs. basal level) and subsequent normalization. Simultaneously, a ''rebound'' of tissue ACh level occurred in the early period of reflow (fourfold vs. ischemic value), followed by gradual normalization after 2 h of reperfusion, whereas a rapid decrease in tissue Ch levels was found after 30 min of reflow. These findings represent the first demonstration of a biphasic release of ACh during ischemia and reperfusion, as assessed by intracerebral microdialysis in gerbils.
引用
收藏
页码:789 / 795
页数:7
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