SIMULTANEOUS DETERMINATION OF FELBAMATE AND 3 METABOLITES IN HUMAN PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：16

作者：

ROMANYSHYN, LA ^{[1
]}

WICHMANN, JK ^{[1
]}

KUCHARCZYK, N ^{[1
]}

SOFIA, RD ^{[1
]}

机构：

[1] WALLACE LABS,DEPT BIOCHEM,CRANBURY,NJ 08512

来源：

THERAPEUTIC DRUG MONITORING | 1994年 / 16卷 / 01期

关键词：

FELBAMATE; METABOLITES; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN PLASMA;

D O I：

10.1097/00007691-199402000-00014

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

An isocratic liquid-chromatographic method employing one extraction step and a 4.6 mm x 150 mm Spherisorb ODS2, 3 mu m high-performance liquid chromatography (HPLC) column using ultraviolet (UV)-absorbance detection at 210 nm has been developed for quantitation of felbamate (FBM) and three felbamate metabolites in 0.100-ml aliquots of human plasma. The linear quantitation range for FBM and the two hydroxy metabolites is 0.781-200 mu g/ml, and that for the monocarbamate metabolite is 0.391-200 mu g/ml.

引用

页码：83 / 89

页数：7

共 17 条

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