OPTICAL RESOLUTION OF AMINO-ACID DERIVATIVES BY MICELLAR ELECTROKINETIC CHROMATOGRAPHY WITH SODIUM N-TETRADECANOYL-L-GLUTAMATE

被引：29

作者：

OTSUKA, K ^{[1
]}

KAWAKAMI, H ^{[1
]}

TAMAKI, W ^{[1
]}

TERABE, S ^{[1
]}

机构：

[1] OSAKA PREFECTURAL COLL TECHNOL,DEPT IND CHEM,NEYAGAWA,OSAKA,JAPAN

来源：

JOURNAL OF CHROMATOGRAPHY A | 1995年 / 716卷 / 1-2期

关键词：

D O I：

10.1016/0021-9673(95)00671-9

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Optical resolution by micellar electrokinetic chromatography with sodium N-tetradecanoyl-L-glutamate (STGlu) was investigated. Similar to the case when using sodium N-dodecanoyl-L-valinate (SDVal), sodium N-dodecanoyl-L-glutamate (SDGlu) and N-dodecanoyl-L-serine (DSer), addition of sodium dodecyl sulfate (SDS), urea and methanol-to STGlu micellar solutions gave improved peak shapes and enhanced the enantioselectivity. With an STGlu-3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate-SDS-urea-methanol solution, five phenylthiohydantoin-DL-amino acids were separated and each enantiomeric pair was optically resolved. The resolution characteristic in the STGlu system, however, was not substantially different from those in SDVal, SDGlu and DSer systems.

引用

页码：319 / 322

页数：4

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