学术探索
学术期刊
新闻热点
数据分析
智能评审

EFFECT OF PHENCYCLIDINE ON PLASMA-CORTICOSTERONE IN MICE

被引：10
作者：
BOGGAN, WO
WALLIS, CJ
OWENS, MH
机构：
来源：
LIFE SCIENCES | 1982年 / 30卷 / 18期
关键词：
D O I：
10.1016/0024-3205(82)90247-8
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Phenylcyclidine [PCP] produced a dose-dependent increase in plasma corticosterone when administered to ovariectomized C57BL/6J mice. This effect was blocked by pretreatment with dexamethasone. The plasma corticosterone concentration after PCP remained elevated after the concentration of PCP observed in plasma and brain tissue began to decline. A stress-like hormonal effect of PCP in mice was demonstrated which appeared to be a result of an action of PCP at the pituitary, hypothalamus or higher CNS level.
引用
收藏
页码：1581 / 1586
页数：6
相关论文
共 18 条
12