NICORANDIL ATTENUATES MYOCARDIAL ACIDOSIS DURING CORONARY-OCCLUSION IN DOGS

被引：23

作者：

ABIKO, Y ^{[1
]}

NISHIMURA, T ^{[1
]}

SAKAI, K ^{[1
]}

机构：

[1] ASAHIKAWA MED COLL, DEPT ORAL SURG, ASAHIKAWA 07811, JAPAN

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1984年 / 81卷 / 02期

关键词：

D O I：

10.1111/j.1476-5381.1984.tb10093.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In dogs anesthetized with pentobarbitone, the left anterior descending coronary artery (LAD) was partially occluded. Before and 30 min after partial occlusion, the myocardial pH was 7.52-7.54 and 6.89-6.91, respectively. Nicorandil (50 .mu.g/kg, i.v.) increased the pH that had been reduced by partial occlusion and this effect lasted at least 60 min. Nicorandil attenuates ischemic myocardial acidosis.

引用

页码：409 / 411

页数：3

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