IMMUNOHISTOCHEMICAL LOCALIZATION OF GLYCATED PROTEIN IN DIABETIC RAT-KIDNEY

被引：2

作者：

YANO, M

MIZUNO, A

SHIMA, K

机构：

[1] Department of Laboratory Medicine, School of Medicine, The University of Tokushima, Tokushima

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 1990年 / 8卷 / 03期

关键词：

Glycated protein; Immunohistochemistry; Kidney; Proximal tubule;

D O I：

10.1016/0168-8227(90)90119-E

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The localization of glycated protein in the kidney of diabetic rats was examined immunohistochemically with antiserum against glucitol-lysine. In diabetic rats the brush border and basement membrane of the proximal convoluted tubules were strongly immunoreactive with the antiserum but in control rats, only the brush border was weakly reactive. The immunoreactive tubules were more abundant in diabetic rats. No immunoreaction was found in any other structures in the kidney. Glycation of the proximal convoluted tubules may be an alteration in diabetic nephropathy. © 1990.

引用

页码：215 / 219

页数：5

共 18 条

[1]

ANDERSEN AR, 1983, DIABETOLOGIA, V25, P496

[2] INCREASED GLYCOSYLATION OF GLOMERULAR BASEMENT-MEMBRANE COLLAGEN IN DIABETES [J].