INFLUENCE OF SITE OF DRUG DELIVERY ON THE SYSTEMIC AVAILABILITY OF METOPROLOL - COMPARISON OF INTRAGASTRIC INFUSION AND 14/190 OROS ADMINISTRATION

被引：6

作者：

WARRINGTON, SJ

BARCLAY, SP

JOHN, VA

SHOTTON, PA

WARDLE, HM

GOOD, W

机构：

[1] CIBA GEIGY PHARMACEUT,DEPT CLIN RES,HORSHAM,W SUSSEX,ENGLAND

[2] CIBA GEIGY CORP,DIV PHARMACEUT,SUMMIT,NJ 07901

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1985年 / 19卷

关键词：

D O I：

10.1111/j.1365-2125.1985.tb02766.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：S219 / S224

页数：6

共 8 条

[1] SIMPLIFIED METHOD FOR DETERMINATION OF OXPRENOLOL AND OTHER BETA-RECEPTOR BLOCKING-AGENTS IN BIOLOGICAL-FLUIDS BY GAS-LIQUID-CHROMATOGRAPHY [J].

DEGEN, PH ;

RIESS, W .

JOURNAL OF CHROMATOGRAPHY, 1976, 121 (01) :72-75

[2] DRUG-METABOLISM BY THE GASTROINTESTINAL MUCOSA [J].

GEORGE, CF .

CLINICAL PHARMACOKINETICS, 1981, 6 (04) :259-274

[3] OSMOTICALLY CONTROLLED-DELIVERY OF METOPROLOL IN MAN - INVIVO PERFORMANCE OF OROS SYSTEMS WITH DIFFERENT DURATIONS OF DRUG RELEASE [J].

GODBILLON, J ;

GERARDIN, A ;

RICHARD, J ;

LEROY, D ;

MOPPERT, J .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1985, 19 :S213-S218

[4]

GODBILLON J, 1981, 1ST P EUR C BIOPH PH, P437

[5]

JOHN VA, 1983, RATE CONTROL DRUG TH, P67

[6] PHARMACOKINETIC STUDIES ON SELECTIVE BETA-1-RECEPTOR ANTAGONIST METOPROLOL IN MAN [J].

REGARDH, CG ;

BORG, KO ;

JOHANSSON, R ;

JOHNSSON, G ;

PALMER, L .

JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1974, 2 (04) :347-364

[7] BIOPHARMACEUTICAL EVALUATION OF OSMOSIN [J].

ROGERS, JD .

CURRENT MEDICAL RESEARCH AND OPINION, 1983, 8 :38-54

[8] KINETIC ANALYSIS OF BLOOD LEVELS + URINARY EXCRETION IN ABSORPTIVE PHASE AFTER SINGLE DOSES OF DRUG [J].

WAGNER, JG ;

NELSON, E .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1964, 53 (11) :1392-&

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