REDUCTION OF BACTERIAL TITERS BY LOW-DOSE ASPIRIN IN EXPERIMENTAL AORTIC-VALVE ENDOCARDITIS

被引：50

作者：

NICOLAU, DP

FREEMAN, CD

NIGHTINGALE, CH

QUINTILIANI, R

COE, CJ

MADERAZO, EG

COOPER, BW

机构：

[1] HARTFORD HOSP,DEPT PHARM,HARTFORD,CT 06115

[2] HARTFORD HOSP,DIV INFECT DIS & ALLERGY IMMUNOL,HARTFORD,CT 06115

[3] UNIV CONNECTICUT,SCH PHARM,STORRS,CT 06268

[4] UNIV CONNECTICUT,SCH MED,FARMINGTON,CT 06032

来源：

INFECTION AND IMMUNITY | 1993年 / 61卷 / 04期

关键词：

D O I：

10.1128/IAI.61.4.1593-1595.1993

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Using a rabbit model of Staphylococcus aureus endocarditis, we studied the effects of aspirin on the natural progression of this infection. Compared with untreated animals, the aspirin-treated animals showed a 30% (P = 0.11) reduction in the weight of the vegetations and an 84% (P = 0.03) reduction in the bacterial titer of the vegetations.

引用

页码：1593 / 1595

页数：3

共 21 条

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