HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC IDENTIFICATION OF RAMIPRIL, AND ITS PRECURSOR ENANTIOMERS USING A CHIRALPAK OT(+)- COLUMN

被引：15

作者：

ABOULENEIN, HY

BAKR, SA

机构：

[1] Drug Development Laboratory, Radionuclide and Cyclotron Operations Department, King Faisal Specialist Hospital and Research Centre, Riyadh, 11211

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1992年 / 18卷 / 09期

关键词：

D O I：

10.3109/03639049209069312

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ramipril and its precursor I enantiomers (all-S and all-R optical isomers were identified by liquid chromatographic method using Chiralcel stationary phase OT(+) column, after derivatization of proline residue with trifloroacetic anhydride to form trifloroacetamide. Maximum resolution (R) of 1.06 was obtained for precursor I enantiomers when chromatogramed as mixture. The method can be applied for optical purity determination of these precursors which are used for ramipril synthesis and also their detection as impurities in ramipril.

引用

页码：1013 / 1022

页数：10