ABSORPTION AND LYMPHATIC UPTAKE OF 5-FLUOROURACIL IN THE RAT FOLLOWING ORAL-ADMINISTRATION OF W/O/W MULTIPLE EMULSIONS

被引:25
作者
OMOTOSHO, JA
FLORENCE, AT
WHATELEY, TL
机构
[1] UNIV STRATHCLYDE,SCH PHARM & PHARMACOL,DEPT PHARM,GLASGOW G1 1XW,SCOTLAND
[2] OBAFEMI AWOLOWO UNIV,FAC PHARM,DEPT PHARMACEUT,IFE,NIGERIA
关键词
Drug delivery; Fluorouracil; 5-; Lymphatic uptake; Multiple emulsion; Oral route;
D O I
10.1016/0378-5173(90)90043-4
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The influence of the nature of the oil phase of w/o/w emulsions on the oral absorption of 5-fluoro[3H]uracil in the rat is described. Liver levels and lymphatic accumulation of the drug following oral administration of w/o/w emulsions were studied. The absorption of 5-fluoro[3H]uracil orally administered in a water/isopropyl myristate/water emulsion was enhanced compared to an aqueous solution while a w/o/w emulsion prepared with octane as the oil phase reduced intestinal uptake. The suggested mechanism underlying the enhancement noted with isopropyl myristate emulsions may be attributed to the inhibitory effect of the oil on the gastric emptying processes. Both emulsion systems showed potential as lymphotropic carriers of water-soluble drugs to the mesenteric lymph nodes following oral administration. © 1990.
引用
收藏
页码:51 / 56
页数:6
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