INSULIN PROTECTS BRAIN-TISSUE AGAINST FOCAL ISCHEMIA IN RATS

被引：32

作者：

IZUMI, Y ^{[1
]}

PINARD, E ^{[1
]}

ROUSSEL, S ^{[1
]}

SEYLAZ, J ^{[1
]}

机构：

[1] UNIV PARIS 07,RECH CEREBROVASC LAB,CNRS,UA 641,10 AVE VERDUN,F-75010 PARIS,FRANCE

来源：

NEUROSCIENCE LETTERS | 1992年 / 144卷 / 1-2期

关键词：

FOCAL CEREBRAL ISCHEMIA; GLUCOSE; INFARCT SIZE; INSULIN; NEUROPROTECTION;

D O I：

10.1016/0304-3940(92)90730-U

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The influence of insulin on the infarct volume due to middle cerebral artery (MCA) occlusion was investigated in rats. A small dose of insulin (1 unit/kg) was injected i.p. just after MCA occlusion. The infarct areas were measured by planimetry from brains perfused with 2,3,5-triphenyltetrazolium-chloride (TTC) 48 h after the occlusion. Systemic variables were measured before and at various times after ischemia. The comparison between insulin-treated (n = 14) and control (n = 13) rats provided evidence that insulin significantly reduced the infarct volume due to MCA occlusion. As insulin minimally and transiently decreased blood glucose, the present results suggest that insulin exerts a beneficial effect directly on the central nervous system.

引用

页码：121 / 123

页数：3

共 21 条

[1] INSULIN EFFECT ON GABA UPTAKE IN ASTROGLIAL PRIMARY CULTURES [J].

BOUHADDI, K ;

THOMOPOULOS, P ;

FAGES, C ;

KHELIL, M ;

TARDY, M .

NEUROCHEMICAL RESEARCH, 1988, 13 (12) :1119-1124

[2] BLOOD-BRAIN-BARRIER TRANSCYTOSIS OF INSULIN IN DEVELOPING RABBITS [J].

DUFFY, KR ;

PARDRIDGE, WM .

BRAIN RESEARCH, 1987, 420 (01) :32-38

[3] EFFECT OF INSULIN ON ACUTE EXPERIMENTAL CEREBRAL-ISCHEMIA IN GERBILS [J].

FUKUOKA, S ;

YEH, HS ;

MANDYBUR, TI ;

TEW, JM .

STROKE, 1989, 20 (03) :396-399

[4] RODENT MODELS OF CEREBRAL-ISCHEMIA [J].

GINSBERG, MD ;

BUSTO, R .

STROKE, 1989, 20 (12) :1627-1642

[5] INSULIN RECEPTORS ARE WIDELY DISTRIBUTED IN CENTRAL NERVOUS-SYSTEM OF RAT [J].

HAVRANKOVA, J ;

ROTH, J .

NATURE, 1978, 272 (5656) :827-829

[6] REDUCTION OF INFARCT VOLUME BY MAGNESIUM AFTER MIDDLE CEREBRAL-ARTERY OCCLUSION IN RATS [J].

IZUMI, Y ;

ROUSSEL, S ;

PINARD, E ;

SEYLAZ, J .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1991, 11 (06) :1025-1030

[7] INSULIN ADMINISTRATION PROTECTS NEUROLOGIC FUNCTION IN CEREBRAL-ISCHEMIA IN RATS [J].

LEMAY, DR ;

GEHUA, L ;

ZELENOCK, GB ;

DALECY, LG .

STROKE, 1988, 19 (11) :1411-1419

[8] INSULIN ADMINISTRATION PROTECTS FROM PARAPLEGIA IN THE RAT AORTIC OCCLUSION MODEL [J].

LEMAY, DR ;

LU, AC ;

ZELENOCK, GB ;

DALECY, LG .

JOURNAL OF SURGICAL RESEARCH, 1988, 44 (04) :352-358

[9] LIMITATIONS OF TETRAZOLIUM SALTS IN DELINEATING INFARCTED BRAIN [J].

LISZCZAK, TM ;

HEDLEYWHYTE, ET ;

ADAMS, JF ;

HAN, DH ;

KOLLURI, VS ;

VACANTI, FX ;

HEROS, RC ;

ZERVAS, NT .

ACTA NEUROPATHOLOGICA, 1984, 65 (02) :150-157

[10]

NISSLEY SP, 1985, HORMONAL PROTEINS PE, P127

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